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KMID : 0356620030180020232
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Journal of Korean Society of Endocrinology
2003 Volume.18 No. 2 p.232 ~ p.238
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A Case of Adrenal Cortical Carcinoma with Liver Metastasis
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Lee Hyeon-Ju
Kim Myung-Soo
Park Hyo-Gyeong
Kim Dae-Jung
Rhee Yu-Mie
Ahn Chul-Woo
Nam Jae-Hyeon
Cha Bong-Soo
Song Yeong-Deug
Han Sang-Won
Lim Sung-Kil
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Abstract
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An adrenal cortical carcinoma is a rare malignancy associated with poor prognosis. On diagnosis, most patients present with large tumor masses, which are often detected at an advanced stage. The most effective treatment is a complete resection, which is the only curative treatment for adrenal cortical carcinomas. The most important prognostic factor is a successful resection of the primary tumor, as long as it is low-grade and has not spread to distant sites. However, with advanced adrenal cortical carcinomas, with distant metastasis, there is no strict effective treatment program, and the prognosis is poor. The case of a 50-year-old female patient, presenting with an adrenal cortical carcinoma and Cushing’s syndrome, who had a long-term survival of 78 months, is reported. The mass was completely resected on diagnosis, but 16 months later liver metastasis was discovered. She had received chemotherapy, with cisplatin, etoposide and bleomycin, for the liver metastasis for a period of 15 months, but with no response, furthermore, the size had increased after 10 months. Afterward, she received her 10th session of intrahepatic artery cisplatin chemotherapy and her 3rd hepatic artery embolization. Although the patient had a large degree of liver metastasis, this was tolerated. The tumor mass is presently not aggravated, and she still survives after 78 months.
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KEYWORD
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Adrenal cortical carcinoma, Liver metastasis, Long-term survival
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